[HTML][HTML] Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites (∗)
P Costantini, BV Chernyak, V Petronilli… - Journal of Biological …, 1996 - ASBMB
After accumulation of a Ca 2⁺ load, the addition of uncoupler to respiring rat liver
mitochondria is followed by opening of the permeability transition pore (MTP), a voltage-
dependent channel sensitive to cyclosporin A. The channel's voltage threshold is profoundly
affected under conditions of oxidative stress, with a shift to more negative values that may
cause MTP opening at physiological membrane potentials. In this paper we further clarify the
mechanisms by which oxidative agents affect the apparent voltage dependence of the MTP …
mitochondria is followed by opening of the permeability transition pore (MTP), a voltage-
dependent channel sensitive to cyclosporin A. The channel's voltage threshold is profoundly
affected under conditions of oxidative stress, with a shift to more negative values that may
cause MTP opening at physiological membrane potentials. In this paper we further clarify the
mechanisms by which oxidative agents affect the apparent voltage dependence of the MTP …