Complex networks orchestrate epithelial–mesenchymal transitions
JP Thiery, JP Sleeman - Nature reviews Molecular cell biology, 2006 - nature.com
Nature reviews Molecular cell biology, 2006•nature.com
Epithelial–mesenchymal transition is an indispensable mechanism during morphogenesis,
as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-
cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far
beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells
arise from an epithelial default status will also have a strong impact in unravelling the
mechanisms that control fibrosis and cancer progression.
as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-
cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far
beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells
arise from an epithelial default status will also have a strong impact in unravelling the
mechanisms that control fibrosis and cancer progression.
Abstract
Epithelial–mesenchymal transition is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
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