The liver is the central organ for metabolism and has strong regenerative capability.
Although the liver has been studied mostly biochemically and histopathologically, genetic
studies using gene‐targeting technology have identified a number of cytokines, intracellular
signaling molecules, and transcription factors involved in liver development and
regeneration. In addition, various in vitro systems such as fetal liver explant culture and
primary culture of fetal liver cells have been established, and the combination of genetic and …