Cross-presentation: a general mechanism for CTL immunity and tolerance
FR Carbone, C Kurts, SRM Bennett, JFAP Miller… - Immunology today, 1998 - cell.com
FR Carbone, C Kurts, SRM Bennett, JFAP Miller, WR Heath
Immunology today, 1998•cell.comMHC class I-restricted presentation is usually associated with the processing of endogenous
antigens. However, this restriction element can present antigens that do not originate within
the presenting cells. Here, Francis Carbone and colleagues describe how such cross-
presentation is critical for cytotoxic T-cell surveillance of peripheral antigens, both self and
foreign, located outside the secondary lymphoid compartment.
antigens. However, this restriction element can present antigens that do not originate within
the presenting cells. Here, Francis Carbone and colleagues describe how such cross-
presentation is critical for cytotoxic T-cell surveillance of peripheral antigens, both self and
foreign, located outside the secondary lymphoid compartment.
Abstract
MHC class I-restricted presentation is usually associated with the processing of endogenous antigens. However, this restriction element can present antigens that do not originate within the presenting cells. Here, Francis Carbone and colleagues describe how such cross-presentation is critical for cytotoxic T-cell surveillance of peripheral antigens, both self and foreign, located outside the secondary lymphoid compartment.
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