ANCA are pathogenic—oh yes they are!
RJ Falk, JC Jennette - Journal of the American Society of …, 2002 - journals.lww.com
During the past two decades, remarkable progress has been made in our understanding of
anti-neutrophil cytoplasmic autoantibodies (ANCA) and the associated diseases. The early
years were marked by the discovery and elucidation of the antigens that were the targets of
the ANCA autoimmune response (1). Myeloperoxidase (MPO) and proteinase-3 (PR3) were
rapidly determined to be the major ANCA autoantigens. Clinical and pathological correlates
of ANCA were described and refined. The reclassification of small-vessel vasculitis ensued …
anti-neutrophil cytoplasmic autoantibodies (ANCA) and the associated diseases. The early
years were marked by the discovery and elucidation of the antigens that were the targets of
the ANCA autoimmune response (1). Myeloperoxidase (MPO) and proteinase-3 (PR3) were
rapidly determined to be the major ANCA autoantigens. Clinical and pathological correlates
of ANCA were described and refined. The reclassification of small-vessel vasculitis ensued …