[HTML][HTML] Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau (∗)
P Seubert, M Mawal-Dewan, R Barbour, R Jakes… - Journal of Biological …, 1995 - ASBMB
Paired helical filaments (PHFs) are the major structural elements of Alzheimer's disease
neurofibrillary lesions, and these filaments are formed from hyperphosphorylated brain tau
known as PHF-tau. Recent studies showed that many previously identified phosphorylated
residues in PHF-tau also are phosphate acceptor sites in fetal and rapidly processed adult
brain tau. However, Ser 262 has been suggested to be uniquely phosphorylated in PHF-tau
and a key regulator of the binding of tau to microtubules. For these reasons, we generated a …
neurofibrillary lesions, and these filaments are formed from hyperphosphorylated brain tau
known as PHF-tau. Recent studies showed that many previously identified phosphorylated
residues in PHF-tau also are phosphate acceptor sites in fetal and rapidly processed adult
brain tau. However, Ser 262 has been suggested to be uniquely phosphorylated in PHF-tau
and a key regulator of the binding of tau to microtubules. For these reasons, we generated a …