NF-κB regulates Fas-mediated apoptosis in HIV-associated nephropathy
MJ Ross, S Martinka, VD D'Agati… - Journal of the American …, 2005 - journals.lww.com
Renal parenchymal injury in HIV-associated nephropathy (HIVAN) is characterized by
epithelial proliferation, dedifferentiation, and apoptosis along the entire length of the
nephron. Although apoptotic cell death in HIVAN has been well documented, the
mechanism for HIV-induced apoptosis is poorly understood. Whether the epithelial
apoptosis in HIVAN is mediated by NF-κB–activated Fas ligand expression was investigated
here. In human HIVAN and HIV-1 transgenic mouse kidney specimens, the expression of …
epithelial proliferation, dedifferentiation, and apoptosis along the entire length of the
nephron. Although apoptotic cell death in HIVAN has been well documented, the
mechanism for HIV-induced apoptosis is poorly understood. Whether the epithelial
apoptosis in HIVAN is mediated by NF-κB–activated Fas ligand expression was investigated
here. In human HIVAN and HIV-1 transgenic mouse kidney specimens, the expression of …