[HTML][HTML] Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

H Shimano, N Yahagi, M Amemiya-Kudo… - Journal of Biological …, 1999 - ASBMB
To elucidate the physiological role of sterol regulatory element-binding protein-1 (SREBP-1),
the hepatic mRNA levels of genes encoding various lipogenic enzymes were estimated in
SREBP-1 gene knockout mice after a fasting-refeeding treatment, which is an established
dietary manipulation for the induction of lipogenic enzymes. In the fasted state, the mRNA
levels of all lipogenic enzymes were consistently low in both wild-type andSREBP-1−/−
mice. However, the absence of SREBP-1 severely impaired the marked induction of hepatic …