[HTML][HTML] Phosphocholine as a pattern recognition ligand for CD361
A Boullier, P Friedman, R Harkewicz, K Hartvigsen… - Journal of lipid …, 2005 - ASBMB
We have previously shown that CD36 recognizes oxidation products of phospholipids on
oxidized LDL (OxLDL) such as 1-palmitoyl-2-(5′-oxovaleroyl)-sn-glycero-3-
phosphocholine (POVPC). The current study was designed to examine whether the
phosphocholine (PC) headgroup in POVPC constitutes an obligatory binding target for
CD36. To examine the contribution of PC in the binding of POVPC to CD36, we used well-
defined synthetic oxidized phospholipids (OxPLs) cross-linked to BSA or to a hexapeptide …
oxidized LDL (OxLDL) such as 1-palmitoyl-2-(5′-oxovaleroyl)-sn-glycero-3-
phosphocholine (POVPC). The current study was designed to examine whether the
phosphocholine (PC) headgroup in POVPC constitutes an obligatory binding target for
CD36. To examine the contribution of PC in the binding of POVPC to CD36, we used well-
defined synthetic oxidized phospholipids (OxPLs) cross-linked to BSA or to a hexapeptide …