HLA expression in uveal melanoma: there is no rule without some exception
MJ Jager, HM Hurks, J Levitskaya, R Kiessling - Human immunology, 2002 - Elsevier
A decrease in the expression of HLA antigens is considered a characteristic of tumor
progression and is considered an important tumor-escape mechanism. In general, HLA
Class I expression is even further decreased on metastases. Tumor cells that loose their
HLA Class I antigens become less susceptible to lysis by specific T cells, but may become
more sensitive to Natural Killer cells. Loss of HLA Class I can be observed at different levels,
ie total loss of Class I, loss of expression of one locus or one haplotype, or even one specific …
progression and is considered an important tumor-escape mechanism. In general, HLA
Class I expression is even further decreased on metastases. Tumor cells that loose their
HLA Class I antigens become less susceptible to lysis by specific T cells, but may become
more sensitive to Natural Killer cells. Loss of HLA Class I can be observed at different levels,
ie total loss of Class I, loss of expression of one locus or one haplotype, or even one specific …