[HTML][HTML] A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2
The relationship between the Src kinase Lyn and Bcl-2 expression was examined in chronic
myelogenous leukemia cells (K562 and LAMA84) displaying a Bcr/Abl-independent form of
imatinib mesylate resistance. K562-R and LAMA-R cells that were markedly resistant to
induction of mitochondrial dysfunction (eg loss of mitochondrial membrane potential, Bax
translocation, cytochrome c, and apoptosis-inducing factor release) and apoptosis by
imatinib mesylate exhibited a pronounced reduction in expression of Bcr/Abl, Bcl-x L, and …
myelogenous leukemia cells (K562 and LAMA84) displaying a Bcr/Abl-independent form of
imatinib mesylate resistance. K562-R and LAMA-R cells that were markedly resistant to
induction of mitochondrial dysfunction (eg loss of mitochondrial membrane potential, Bax
translocation, cytochrome c, and apoptosis-inducing factor release) and apoptosis by
imatinib mesylate exhibited a pronounced reduction in expression of Bcr/Abl, Bcl-x L, and …