The reticuloendothelial system and low density lipoprotein metabolism in the rabbit

CJ Packard, HR Slater, J Shepherd - … et Biophysica Acta (BBA)-Lipids and …, 1982 - Elsevier
This study examines the role of the reticuloendothelial system in the metabolism and tissue
uptake ofchemically modified human low density lipoprotein (LDL) in rabbits. Treatment with
1, 2-cyclohexanedioneor HCHO/NaBH 4 abolishes receptor-mediated catabolism of the
lipoprotein and restricts its clearance toreceptor-independent pathways. When the plasma
clearances of the two modified lipoproteins were measured in rabbits the 1, 2-
cyclohexanedione-treated LDL was removed 19% faster (P< 0.001) thanHCHO/NaBH 4 …