Liver X receptors (LXRs) are ligand-activated transcription factors involved in the control of
lipid metabolism and inflammation. Several studies have recently shown that LXRs promote
reverse cholesterol transport and inhibit atherosclerosis. Our study investigated whether
LXRs affect macrophage uptake of LDL by human monocyte-derived macrophages. We
have previously shown that human monocytes differentiated into macrophages with
macrophage-colony-stimulating factor (M-CSF) constitutively take up large amounts of native …