ContextThe mechanisms that drive progression from fatty liver to steatohepatitis and
cirrhosis are unknown. In animal models, obese mice with fatty livers are vulnerable to liver
adenosine triphosphate (ATP) depletion and necrosis, suggesting that altered hepatic
energy homeostasis may be involved. ObjectiveTo determine if patients with fatty liver
disease exhibit impaired recovery from hepatic ATP depletion. DesignLaboratory analysis of
liver ATP stores monitored by nuclear magnetic resonance spectroscopy before and after …