B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells

M Yang, H Hase, D Legarda-Addison… - The Journal of …, 2005 - journals.aai.org
M Yang, H Hase, D Legarda-Addison, L Varughese, B Seed, AT Ting
The Journal of Immunology, 2005journals.aai.org
B cell maturation Ag (BCMA), a member of the TNFR superfamily expressed on B cells,
binds to a proliferation-inducing ligand (APRIL) and B cell-activating factor of the TNF family
(BAFF) but the specific B cell responses regulated by BCMA remain unclear. This study
demonstrates that ligation of A20 B cells transfected with BCMA induces the expression of
CD40, CD80/B7-1, CD86/B7-2, MHC class II, and CD54/ICAM-1, which subsequently
enhances the presentation of OVA peptide Ag to DO11. 10 T cells. BCMA expression in …
Abstract
B cell maturation Ag (BCMA), a member of the TNFR superfamily expressed on B cells, binds to a proliferation-inducing ligand (APRIL) and B cell-activating factor of the TNF family (BAFF) but the specific B cell responses regulated by BCMA remain unclear. This study demonstrates that ligation of A20 B cells transfected with BCMA induces the expression of CD40, CD80/B7-1, CD86/B7-2, MHC class II, and CD54/ICAM-1, which subsequently enhances the presentation of OVA peptide Ag to DO11. 10 T cells. BCMA expression in murine splenic B cells can be induced with IL-4 and IL-6, allowing subsequent treatment with APRIL or agonist anti-BCMA to similarly induce Ag presentation. A comparative analysis of hybrid receptors of TNFR2 fused to the cytoplasmic domains of APRIL/BAFF receptors found that only BCMA, but not transmembrane activator and calcium-modulator and cyclophilin ligand interactor or BAFF-R, is capable of activating Ag presentation. Although all three receptors can trigger NF-κB signaling, only BCMA activates the JNK pathway conferring on BCMA the specific ability to activate this Ag presentation response.
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