The multifaceted roles of TRAFs in the regulation of B-cell function

GA Bishop - Nature Reviews Immunology, 2004 - nature.com
Nature Reviews Immunology, 2004nature.com
Tumour-necrosis factor receptor (TNFR)-associated factors (TRAFs) are cytoplasmic adaptor
proteins that are important in lymphocyte activation and apoptosis. Many studies of TRAFs
have used models of exogenous overexpression by non-lymphoid cells. However, the
actions of TRAFs present at normal levels in lymphoid cells often differ considerably from
those that have been established in non-lymphocyte overexpression models. As I discuss
here, information obtained from studying these molecules in physiological settings in B cells …
Abstract
Tumour-necrosis factor receptor (TNFR)-associated factors (TRAFs) are cytoplasmic adaptor proteins that are important in lymphocyte activation and apoptosis. Many studies of TRAFs have used models of exogenous overexpression by non-lymphoid cells. However, the actions of TRAFs present at normal levels in lymphoid cells often differ considerably from those that have been established in non-lymphocyte overexpression models. As I discuss here, information obtained from studying these molecules in physiological settings in B cells reveals that they have several roles, which are both unique and overlapping. These include activation of kinases and transcription factors, and interactions with other signalling proteins, culminating in the induction or inhibition of biological functions.
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