[HTML][HTML] δBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF
AL Gavin, D Aït-Azzouzene, CF Ware… - Journal of Biological …, 2003 - ASBMB
The tumor necrosis family member BAFF is limiting for the survival of follicular B
lymphocytes, but excessive BAFF signaling can lead to autoimmunity, suggesting that its
activity must be tightly regulated. We have identified a conserved alternate splice isoform of
BAFF, called ΔBAFF, which lacks 57 nt encoding the A–A1 loop and is co-expressed with
BAFF in many mouse and human myeloid cells. Mouse ΔBAFF appears on the plasma
membrane, but unlike BAFF it is inefficiently released by proteolysis. ΔBAFF can associate …
lymphocytes, but excessive BAFF signaling can lead to autoimmunity, suggesting that its
activity must be tightly regulated. We have identified a conserved alternate splice isoform of
BAFF, called ΔBAFF, which lacks 57 nt encoding the A–A1 loop and is co-expressed with
BAFF in many mouse and human myeloid cells. Mouse ΔBAFF appears on the plasma
membrane, but unlike BAFF it is inefficiently released by proteolysis. ΔBAFF can associate …