Bcl-2 inhibition of autophagy: a new route to cancer?
S Pattingre, B Levine - Cancer research, 2006 - AACR
S Pattingre, B Levine
Cancer research, 2006•AACRBcl-2 was the first identified cellular protein that functions as an oncogene by blocking
apoptotic cell death. Beclin 1, the first identified mammalian autophagy gene product, is a
haploinsufficient tumor suppressor that was originally isolated as a Bcl-2-interacting protein.
We recently showed that Bcl-2 negatively regulates Beclin 1-dependent autophagy and
Beclin 1-dependent autophagic cell death. These findings raise the possibility that Bcl-2
family members may function as oncogenes not only by blocking apoptosis but also by …
apoptotic cell death. Beclin 1, the first identified mammalian autophagy gene product, is a
haploinsufficient tumor suppressor that was originally isolated as a Bcl-2-interacting protein.
We recently showed that Bcl-2 negatively regulates Beclin 1-dependent autophagy and
Beclin 1-dependent autophagic cell death. These findings raise the possibility that Bcl-2
family members may function as oncogenes not only by blocking apoptosis but also by …
Abstract
Bcl-2 was the first identified cellular protein that functions as an oncogene by blocking apoptotic cell death. Beclin 1, the first identified mammalian autophagy gene product, is a haploinsufficient tumor suppressor that was originally isolated as a Bcl-2-interacting protein. We recently showed that Bcl-2 negatively regulates Beclin 1-dependent autophagy and Beclin 1-dependent autophagic cell death. These findings raise the possibility that Bcl-2 family members may function as oncogenes not only by blocking apoptosis but also by blocking autophagy. (Cancer Res 2006; 66(6): 2885-8)
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