[HTML][HTML] Prostaglandin E2 increases growth and motility of colorectal carcinoma cells
H Sheng, J Shao, MK Washington… - Journal of Biological …, 2001 - ASBMB
Chronic use of nonsteroidal anti-inflammatory drugs results in a significant reduction of risk
and mortality from colorectal cancer in humans. All of the mechanism (s) by which
nonsteroidal anti-inflammatory drugs exert their protective effects are not completely
understood, but they are known to inhibit cyclooxygenase activity. The cyclooxygenase
enzymes catalyze a key reaction in the conversion of arachidonic acid to prostaglandins,
such as prostaglandin E 2 (PGE 2). Here we demonstrate that PGE 2 treatment of LS-174 …
and mortality from colorectal cancer in humans. All of the mechanism (s) by which
nonsteroidal anti-inflammatory drugs exert their protective effects are not completely
understood, but they are known to inhibit cyclooxygenase activity. The cyclooxygenase
enzymes catalyze a key reaction in the conversion of arachidonic acid to prostaglandins,
such as prostaglandin E 2 (PGE 2). Here we demonstrate that PGE 2 treatment of LS-174 …