[HTML][HTML] 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer

MG Backlund, JR Mann, VR Holla, FG Buchanan… - Journal of Biological …, 2005 - ASBMB
Prostaglandin E 2 (PGE 2) can stimulate tumor progression by modulating several
proneoplastic pathways, including proliferation, angiogenesis, cell migration, invasion, and
apoptosis. Although steady-state tissue levels of PGE 2 stem from relative rates of
biosynthesis and breakdown, most reports examining PGE 2 have focused solely on the
cyclooxygenase-dependent formation of this bioactive lipid. Enzymatic degradation of PGE 2
involves the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). The …