High frequency of t (12; 21) in childhood B-lineage acute lymphoblastic leukemia
SP Romana, H Poirel, M Leconiat, MA Flexor… - 1995 - ashpublications.org
SP Romana, H Poirel, M Leconiat, MA Flexor, M Mauchauffe, P Jonveaux, EA Macintyre…
1995•ashpublications.orgThe recurrent t (12; 21)(p12; q22) translocation fuses two genes, TEL and AML1, that have
previously been shown to be independently involved in myeloid malignant proliferations. A
search for rearrangement of the TEL locus in the region known to be involved in t (12; 21)
was performed by Southern blotting in a panel of hematopoietic malignancies. The presence
of at (12; 21) was confirmed by fluorescence in situ hybridization (FISH) and/or reverse
transcriptase (RT)-polymerase chain reaction (PCR). We report that fusion of TEL to AML1 is …
previously been shown to be independently involved in myeloid malignant proliferations. A
search for rearrangement of the TEL locus in the region known to be involved in t (12; 21)
was performed by Southern blotting in a panel of hematopoietic malignancies. The presence
of at (12; 21) was confirmed by fluorescence in situ hybridization (FISH) and/or reverse
transcriptase (RT)-polymerase chain reaction (PCR). We report that fusion of TEL to AML1 is …
The recurrent t(12;21)(p12;q22) translocation fuses two genes, TEL and AML1, that have previously been shown to be independently involved in myeloid malignant proliferations. A search for rearrangement of the TEL locus in the region known to be involved in t(12;21) was performed by Southern blotting in a panel of hematopoietic malignancies. The presence of a t(12;21) was confirmed by fluorescence in situ hybridization (FISH) and/or reverse transcriptase (RT)-polymerase chain reaction (PCR). We report that fusion of TEL to AML1 is specifically observed in at least 16% of the childhood B-lineage acute lymphoblastic leukemia (ALL) investigated, none of which had been previously identified as harboring t(12;21).
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