[HTML][HTML] Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-κB transactivation via phosphorylation of the p65 subunit
MK Jang, YH Goo, YC Sohn, YS Kim, SK Lee… - Journal of Biological …, 2001 - ASBMB
Calmodulin-dependent protein kinase IV (CaMKIV) is a key mediator of Ca 2+-induced gene
expression. In this study, CaMKIV was found to directly associate with and phosphorylate the
nuclear factor-κB (NFκB) component p65 both in vitro and in vivo. The phosphorylation of
p65 by CaMKIV resulted in recruitment of transcription coactivator cAMP-response element-
binding protein-binding protein and concomitant release of corepressor silencing mediator
for retinoid and thyroid hormone receptors, as demonstrated by the glutathioneS-transferase …
expression. In this study, CaMKIV was found to directly associate with and phosphorylate the
nuclear factor-κB (NFκB) component p65 both in vitro and in vivo. The phosphorylation of
p65 by CaMKIV resulted in recruitment of transcription coactivator cAMP-response element-
binding protein-binding protein and concomitant release of corepressor silencing mediator
for retinoid and thyroid hormone receptors, as demonstrated by the glutathioneS-transferase …