[HTML][HTML] Transforming growth factor-β1 decreases expression of the epithelial sodium channel αENaC and alveolar epithelial vectorial sodium and fluid transport via …
J Frank, J Roux, H Kawakatsu, G Su… - Journal of Biological …, 2003 - ASBMB
Acute lung injury (ALI) is characterized by the flooding of the alveolar airspaces with protein-
rich edema fluid and diffuse alveolar damage. We have previously reported that
transforming growth factor-β1 (TGF-β1) is a critical mediator of ALI after intratracheal
administration of bleomycin or Escherichia coli endotoxin, at least in part due to effects on
lung endothelial and alveolar epithelial permeability. In the present study, we hypothesized
that TGF-β1 would also decrease vectorial ion and water transport across the distal lung …
rich edema fluid and diffuse alveolar damage. We have previously reported that
transforming growth factor-β1 (TGF-β1) is a critical mediator of ALI after intratracheal
administration of bleomycin or Escherichia coli endotoxin, at least in part due to effects on
lung endothelial and alveolar epithelial permeability. In the present study, we hypothesized
that TGF-β1 would also decrease vectorial ion and water transport across the distal lung …
