Vagus nerve stimulation: 2-year outcomes for bipolar versus unipolar treatment-resistant depression
AA Nierenberg, JE Alpert, EE Gardner-Schuster… - Biological …, 2008 - Elsevier
BACKGROUND: The outcome of vagus nerve stimulation (VNS) for patients with bipolar
treatment-resistant depression (TRD) has not been well characterized. This study describes
the outcome of VNS for bipolar TRD patients participating in the acute and longitudinal
pivotal trials and compares their outcome with unipolar TRD patients in the same trials.
METHODS: Of 235 participants enrolled in the acute study, 25 (11%) were diagnosed with
DSM-IV bipolar I or II disorder. A sham-controlled 12-week trial of VNS preceded 2 years of …
treatment-resistant depression (TRD) has not been well characterized. This study describes
the outcome of VNS for bipolar TRD patients participating in the acute and longitudinal
pivotal trials and compares their outcome with unipolar TRD patients in the same trials.
METHODS: Of 235 participants enrolled in the acute study, 25 (11%) were diagnosed with
DSM-IV bipolar I or II disorder. A sham-controlled 12-week trial of VNS preceded 2 years of …