Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels
WC Drevets, JL Price, ME Bardgett, T Reich… - Pharmacology …, 2002 - Elsevier
In a previous positron emission tomography (PET) study of major depression, we
demonstrated that cerebral blood flow was increased in the left amygdala in unipolar
depressives with familial pure depressive disease (FPDD) relative to healthy controls [J.
Neurosci. 12 (1992) 3628.]. These measures were obtained from relatively low-resolution
PET images using a stereotaxic method based upon skull X-ray landmarks. The current
experiments aimed to replicate and extend these results using higher-resolution glucose …
demonstrated that cerebral blood flow was increased in the left amygdala in unipolar
depressives with familial pure depressive disease (FPDD) relative to healthy controls [J.
Neurosci. 12 (1992) 3628.]. These measures were obtained from relatively low-resolution
PET images using a stereotaxic method based upon skull X-ray landmarks. The current
experiments aimed to replicate and extend these results using higher-resolution glucose …