Hepatocyte growth factor treatment ameliorates diarrhea and bowel inflammation in a rat model of inflammatory bowel disease
LG Arthur, MZ Schwartz, KA Kuenzler, R Birbe - Journal of pediatric surgery, 2004 - Elsevier
BACKGROUND/PURPOSE: Transfection of the HLA-B27 gene into normal Fischer rats
induces phenotypic changes similar to inflammatory bowel disease (IBD). This study
investigated the benefits of 2 doses of hepatocyte growth factor (HGF) on the manifestations
of IBD in this rat model. METHODS: Fischer rats and HLA-B27 rats were divided into 4
groups: Fischer rats treated with saline, HLA-B27 rats treated with saline, HGF at 150
μg/kg/d, and HGF at 300 μg/kg/d. HGF or saline was infused for 14 days via an osmotic …
induces phenotypic changes similar to inflammatory bowel disease (IBD). This study
investigated the benefits of 2 doses of hepatocyte growth factor (HGF) on the manifestations
of IBD in this rat model. METHODS: Fischer rats and HLA-B27 rats were divided into 4
groups: Fischer rats treated with saline, HLA-B27 rats treated with saline, HGF at 150
μg/kg/d, and HGF at 300 μg/kg/d. HGF or saline was infused for 14 days via an osmotic …