Neuregulin 1 (NRG1) is a leading schizophrenia susceptibility gene. The NRG1 locus on
chromosome 8p shows linkage to the disorder, and genetic association has been found
between schizophrenia and various non-coding polymorphisms and haplotypes, especially
at the 5′ end of the NRG1 gene, in many but not all case-control and family studies. NRG1
is a pleiotropic growth factor, important in nervous system development and functioning;
roles include the modulation of neuronal migration, synaptogenesis, gliogenesis, neuron …