The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
HD Schmidt, RS Duman - Behavioural pharmacology, 2007 - journals.lww.com
Major depressive disorder (MDD) is characterized by structural and neurochemical changes
in limbic structures, including the hippocampus, that regulate mood and cognitive functions.
Hippocampal atrophy is observed in patients with depression and this effect is blocked or
reversed by antidepressant treatments. Brain-derived neurotrophic factor and other
neurotrophic/growth factors are decreased in postmortem hippocampal tissue from suicide
victims, which suggests that altered trophic support could contribute to the pathophysiology …
in limbic structures, including the hippocampus, that regulate mood and cognitive functions.
Hippocampal atrophy is observed in patients with depression and this effect is blocked or
reversed by antidepressant treatments. Brain-derived neurotrophic factor and other
neurotrophic/growth factors are decreased in postmortem hippocampal tissue from suicide
victims, which suggests that altered trophic support could contribute to the pathophysiology …