Molecular evidence for mitochondrial dysfunction in bipolar disorder

C Konradi, M Eaton, ML MacDonald… - Archives of general …, 2004 - jamanetwork.com
Background The disease mechanism of bipolar disorder remains unknown. Recent studies
have provided evidence for abnormal gene expression in bipolar disorder. Objective To
determine the expression of 12 558 nuclear genes in the human hippocampus in healthy
control subjects and those with bipolar disorder or schizophrenia. Design We used gene
arrays to study messenger RNA expression. Data were verified with a real-time quantitative
polymerase chain reaction assay. Subjects We studied 10 healthy control subjects, 9 …