Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging
A Bertolino, M Frye, JH Callicott, VS Mattay, R Rakow… - Biological …, 2003 - Elsevier
BACKGROUND: The brain regions involved in the pathophysiology of bipolar disorder have
not been definitively determined. Previous studies have suggested possible involvement of
the hippocampus and of prefrontal regions. Proton magnetic resonance spectroscopic
imaging (1H-MRSI) allows measurement of N-acetylaspartate (NAA, marker of neuronal
integrity), choline-containing compounds (CHO), and creatine+ phosphocreatine (CRE) in
multiple brain regions. The objective of this study was to assess possible NAA reductions in …
not been definitively determined. Previous studies have suggested possible involvement of
the hippocampus and of prefrontal regions. Proton magnetic resonance spectroscopic
imaging (1H-MRSI) allows measurement of N-acetylaspartate (NAA, marker of neuronal
integrity), choline-containing compounds (CHO), and creatine+ phosphocreatine (CRE) in
multiple brain regions. The objective of this study was to assess possible NAA reductions in …