Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder
JJ Pillai, L Friedman, TA Stuve, S Trinidad… - Psychiatry Research …, 2002 - Elsevier
Several reports have noted an increase in white matter hyperintensities (WMH) on MRI
scans of adult patients with bipolar disorder. We investigated whether this increase was also
evident in a group of adolescent patients with bipolar disorder. The sample consisted of 15
bipolar patients, 19 patients with schizophrenia and 16 healthy comparison subjects. All
subjects were adolescents. WMH were blindly rated on T2-weighted and PD-weighted MRI
scans using our own scale with documented inter-rater reliability. WMH were present in 10 …
scans of adult patients with bipolar disorder. We investigated whether this increase was also
evident in a group of adolescent patients with bipolar disorder. The sample consisted of 15
bipolar patients, 19 patients with schizophrenia and 16 healthy comparison subjects. All
subjects were adolescents. WMH were blindly rated on T2-weighted and PD-weighted MRI
scans using our own scale with documented inter-rater reliability. WMH were present in 10 …