Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical γ-aminobutyric acid neurons in subjects with schizophrenia
DW Volk, MC Austin, JN Pierri… - Archives of general …, 2000 - jamanetwork.com
Background Markers of γ-aminobutyric acid (GABA) neurotransmission seem to be altered in
the prefrontal cortex (PFC) of subjects with schizophrenia. We sought to determine whether
the expression of the messenger RNA (mRNA) for the synthesizing enzyme of GABA,
glutamic acid decarboxylase 67 (GAD 67), is decreased in the PFC of subjects with
schizophrenia, whether this change is present in all or only some GABA neurons, and
whether long-term treatment with haloperidol decanoate contributes to altered GAD 67 …
the prefrontal cortex (PFC) of subjects with schizophrenia. We sought to determine whether
the expression of the messenger RNA (mRNA) for the synthesizing enzyme of GABA,
glutamic acid decarboxylase 67 (GAD 67), is decreased in the PFC of subjects with
schizophrenia, whether this change is present in all or only some GABA neurons, and
whether long-term treatment with haloperidol decanoate contributes to altered GAD 67 …