Neuronal and glial somal size in the prefrontal cortex: a postmortem morphometric study of schizophrenia and Huntington disease
G Rajkowska, LD Selemon… - Archives of general …, 1998 - jamanetwork.com
Background The cortex of patients with schizophrenia exhibits a deficit in neuropil, but the
nature and extent of cellular abnormalities remain unclear. To gain further insight into this
abnormality, neuronal and glial somal size were analyzed in postmortem brains from 9
patients with schizophrenia, 10 normal (control) patients, and 7 patients with Huntington
disease, the latter representing a known neurodegenerative disorder. Methods A 3-
dimensional image analyzer was used to measure the perimeters of 10722 neuronal and …
nature and extent of cellular abnormalities remain unclear. To gain further insight into this
abnormality, neuronal and glial somal size were analyzed in postmortem brains from 9
patients with schizophrenia, 10 normal (control) patients, and 7 patients with Huntington
disease, the latter representing a known neurodegenerative disorder. Methods A 3-
dimensional image analyzer was used to measure the perimeters of 10722 neuronal and …