[HTML][HTML] The reduced neuropil hypothesis: a circuit based model of schizophrenia
LD Selemon, PS Goldman-Rakic - Biological psychiatry, 1999 - Elsevier
Schizophrenia is a disease in which morphologic abnor-malities have proven to be both
subtle and elusive. Indeed, the most notable observation is the normal appearance of the
schizophrenic brain, accounting in large part for the skepticism that reigned throughout most
of this century concerning a structural basis for the disorder (Plum 1972). Over the past 2
decades, quantitative approaches in neuroanatomy have opened a new era in the study of
neuropathology in schizophrenia (Weinberger and Wyatt 1982; Roberts and Crow 1987; …
subtle and elusive. Indeed, the most notable observation is the normal appearance of the
schizophrenic brain, accounting in large part for the skepticism that reigned throughout most
of this century concerning a structural basis for the disorder (Plum 1972). Over the past 2
decades, quantitative approaches in neuroanatomy have opened a new era in the study of
neuropathology in schizophrenia (Weinberger and Wyatt 1982; Roberts and Crow 1987; …