Anatomical evidence of impaired feedforward auditory processing in schizophrenia
BACKGROUND: Somal volumes of pyramidal cells are reduced within feedforward but not
feedback circuits in areas 41 and 42 of the auditory cortex of subjects with schizophrenia.
Because neuronal somal volume depends on both the number of axonal terminations onto
and furnished by the neuron, we hypothesized that axon terminal densities are reduced in
feedforward but not feedback auditory pathways in subjects with schizophrenia. METHODS:
We used stereologic methods to quantify the density of a marker of axon terminals …
feedback circuits in areas 41 and 42 of the auditory cortex of subjects with schizophrenia.
Because neuronal somal volume depends on both the number of axonal terminations onto
and furnished by the neuron, we hypothesized that axon terminal densities are reduced in
feedforward but not feedback auditory pathways in subjects with schizophrenia. METHODS:
We used stereologic methods to quantify the density of a marker of axon terminals …