Randomized controlled trial of the effect on Quality of Life of second-vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic …
Context Second-generation (atypical) antipsychotics (SGAs) are more expensive than first-
generation (typical) antipsychotics (FGAs) but are perceived to be more effective, with fewer
adverse effects, and preferable to patients. Most evidence comes from short-term efficacy
trials of symptoms. Objective To test the hypothesis that in people with schizophrenia
requiring a change in treatment, SGAs other than clozapine are associated with improved
quality of life across 1 year compared with FGAs. Design A noncommercially funded …
generation (typical) antipsychotics (FGAs) but are perceived to be more effective, with fewer
adverse effects, and preferable to patients. Most evidence comes from short-term efficacy
trials of symptoms. Objective To test the hypothesis that in people with schizophrenia
requiring a change in treatment, SGAs other than clozapine are associated with improved
quality of life across 1 year compared with FGAs. Design A noncommercially funded …