Regionally specific disturbance of dorsolateral prefrontal–hippocampal functional connectivity in schizophrenia
AS Meyer-Lindenberg, RK Olsen… - Archives of general …, 2005 - jamanetwork.com
Background Two brain regions often implicated in schizophrenia are the dorsolateral
prefrontal cortex (DLPFC) and the hippocampal formation (HF). It has been hypothesized
that the pathophysiology of the disorder might involve an alteration of functional interactions
between medial temporal and prefrontal areas. Methods We used neuroimaging data
acquired during a working memory challenge and a sensorimotor control task in 22
medication-free schizophrenic patients and 22 performance-, age-, and sex-matched …
prefrontal cortex (DLPFC) and the hippocampal formation (HF). It has been hypothesized
that the pathophysiology of the disorder might involve an alteration of functional interactions
between medial temporal and prefrontal areas. Methods We used neuroimaging data
acquired during a working memory challenge and a sensorimotor control task in 22
medication-free schizophrenic patients and 22 performance-, age-, and sex-matched …