Obsessive-compulsive disorder and serotonin: is there a connection?
TR Insel, EA Mueller, I Alterman, M Linnoila… - Biological …, 1985 - Elsevier
Reports of the antiobsessional efficacy of clomipramine have led to a “serotonin hypothesis”
of obsessive-compulsive disorder (OCD). To test this hypothesis, 16 outpatients with DSM-III
OCD were studied using several measures of serotonergic function. Platelet 3 H-imipramine
binding and serotonin uptake were not significantly different between the OCD patients and
a normal, age-matched control group. The level of the metabolite 5-hydroxyindoleacetic acid
(5-HIAA) in cerebrospinal fluid (CSF) was significantly higher in a small cohort of …
of obsessive-compulsive disorder (OCD). To test this hypothesis, 16 outpatients with DSM-III
OCD were studied using several measures of serotonergic function. Platelet 3 H-imipramine
binding and serotonin uptake were not significantly different between the OCD patients and
a normal, age-matched control group. The level of the metabolite 5-hydroxyindoleacetic acid
(5-HIAA) in cerebrospinal fluid (CSF) was significantly higher in a small cohort of …