[CITATION][C] Double-blind comparative study of clomipramine and amitriptyline in obsessive neurosis
J Ananth, JC Pecknold, N Van Den Steen… - Progress in neuro …, 1981 - Elsevier
1. The efficacy of clomipramine hydrochloride in severe obsessive compulsive neurosis
(OCN) was compared with that of amitriptyline in a four week randomized double-blind trial.
2. 2. Clomipramine but not amitriptyline produced statistically significant improvement in the
obsessive symptoms, depression and anxiety. 3. 3. The lack of significant effect of
amitriptyline on anxiety and depression may be due to its inability to improve the primary
obsessive symptoms. 4. 4. No serious adverse effects were encountered in either drug …
(OCN) was compared with that of amitriptyline in a four week randomized double-blind trial.
2. 2. Clomipramine but not amitriptyline produced statistically significant improvement in the
obsessive symptoms, depression and anxiety. 3. 3. The lack of significant effect of
amitriptyline on anxiety and depression may be due to its inability to improve the primary
obsessive symptoms. 4. 4. No serious adverse effects were encountered in either drug …