Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder
PD Arnold, T Sicard, E Burroughs… - Archives of general …, 2006 - jamanetwork.com
Context There is strong evidence from family and twin studies that genetic determinants play
an important role in the etiology of obsessive-compulsive disorder (OCD). In the only
genome scan of OCD to date that we are aware of, suggestive linkage was reported to the
chromosomal region 9p24, a finding that was subsequently replicated. This region contains
the gene encoding the neuronal glutamate transporter, SLC1A1. SLC1A1represents an
excellent candidate gene for OCD based on evidence from neuroimaging and animal …
an important role in the etiology of obsessive-compulsive disorder (OCD). In the only
genome scan of OCD to date that we are aware of, suggestive linkage was reported to the
chromosomal region 9p24, a finding that was subsequently replicated. This region contains
the gene encoding the neuronal glutamate transporter, SLC1A1. SLC1A1represents an
excellent candidate gene for OCD based on evidence from neuroimaging and animal …