Serologic studies of children with Tourette syndrome (TS) have detected anti-neuronal
antibodies but their role in TS has not been explored. Stereotypies and episodic utterances,
analogous to involuntary movements seen in TS, were induced in rats by intrastriatal
microinfusion of TS sera or gamma immunoglobulins (IgG) under noninflammatory
conditions, as found in TS. Immunohistochemical analysis confirmed the presence of IgG
selectively bound to striatal neurons. These data support the hypothesis that binding of an …