Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease
F Hong, S Radaeva, H Pan, Z Tian, R Veech, B Gao - Hepatology, 2004 - journals.lww.com
Fatty liver, formerly associated predominantly with excessive alcohol intake, is now also
recognized as a complication of obesity and an important precursor state to more severe
forms of liver pathology indluding ischemia/reperfusion injury. No standard protocol for
treating fatty liver exists at this time. We therefore examined the effects of 10 days of
interleukin 6 (IL-6) injection in 3 murine models of fatty liver: leptin deficient ob/ob mice,
ethanol-fed mice, and mice fed a high-fat diet. In all 3 models, IL-6 injection decreased …
recognized as a complication of obesity and an important precursor state to more severe
forms of liver pathology indluding ischemia/reperfusion injury. No standard protocol for
treating fatty liver exists at this time. We therefore examined the effects of 10 days of
interleukin 6 (IL-6) injection in 3 murine models of fatty liver: leptin deficient ob/ob mice,
ethanol-fed mice, and mice fed a high-fat diet. In all 3 models, IL-6 injection decreased …