[HTML][HTML] Ecto 5′-nucleotidase and nonspecific alkaline phosphatase: two AMP-hydrolyzing ectoenzymes with distinct roles in human airways
M Picher, LH Burch, AJ Hirsh, J Spychala… - Journal of Biological …, 2003 - ASBMB
In human airways, extracellular adenosine regulates epithelial functions supporting
mucociliary clearance, an important airway defense mechanism against bacterial infection.
Thus, defining the mechanisms of adenosine generation is critical for elucidating the role of
this nucleoside in airway homeostasis. In this study, we identified the source of adenosine
on the mucosal surface of human airway epithelia. Polarized primary cultures of human
nasal or bronchial epithelial cells were assayed for transepithelial transport, cytosolic and …
mucociliary clearance, an important airway defense mechanism against bacterial infection.
Thus, defining the mechanisms of adenosine generation is critical for elucidating the role of
this nucleoside in airway homeostasis. In this study, we identified the source of adenosine
on the mucosal surface of human airway epithelia. Polarized primary cultures of human
nasal or bronchial epithelial cells were assayed for transepithelial transport, cytosolic and …