[HTML][HTML] Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARα target genes in rat liver
R Ringseis, A Muschick, K Eder - The Journal of nutrition, 2007 - Elsevier
Alcoholic fatty liver results from an impaired fatty acid catabolism due to blockade of PPARα
and increased lipogenesis due to activation of sterol regulatory element-binding protein
(SREBP)-1c. Because both oxidized fats (OF) and conjugated linoleic acids (CLA) have
been demonstrated in rats to activate hepatic PPARα, we tested the hypothesis that these
fats are able to prevent ethanol-induced triacylglycerol accumulation in the liver by
upregulation of PPARα-responsive genes. Forty-eight male rats were assigned to 6 groups …
and increased lipogenesis due to activation of sterol regulatory element-binding protein
(SREBP)-1c. Because both oxidized fats (OF) and conjugated linoleic acids (CLA) have
been demonstrated in rats to activate hepatic PPARα, we tested the hypothesis that these
fats are able to prevent ethanol-induced triacylglycerol accumulation in the liver by
upregulation of PPARα-responsive genes. Forty-eight male rats were assigned to 6 groups …