[HTML][HTML] Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury
K Zhao, GM Zhao, D Wu, Y Soong, AV Birk… - Journal of Biological …, 2004 - ASBMB
Reactive oxygen species (ROS) play a key role in promoting mitochondrial cytochrome c
release and induction of apoptosis. ROS induce dissociation of cytochrome c from
cardiolipin on the inner mitochondrial membrane (IMM), and cytochrome c may then be
released via mitochondrial permeability transition (MPT)-dependent or MPT-independent
mechanisms. We have developed peptide antioxidants that target the IMM, and we used
them to investigate the role of ROS and MPT in cell death caused by t-butylhydroperoxide …
release and induction of apoptosis. ROS induce dissociation of cytochrome c from
cardiolipin on the inner mitochondrial membrane (IMM), and cytochrome c may then be
released via mitochondrial permeability transition (MPT)-dependent or MPT-independent
mechanisms. We have developed peptide antioxidants that target the IMM, and we used
them to investigate the role of ROS and MPT in cell death caused by t-butylhydroperoxide …