Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses
Context A role for the centrosome has been suggested in the pathology of major mental
illnesses, especially schizophrenia (SZ). Objectives To show that pericentriolar material 1
protein (PCM1) forms a complex at the centrosome with disrupted-in-schizophrenia 1
(DISC1) and Bardet-Biedl syndrome 4 protein (BBS4), which provides a crucial pathway for
cortical development associated with the pathology of SZ. To identify mutations in
thePCM1gene in an SZ population. Design Interaction of DISC1, PCM1, and BBS proteins …
illnesses, especially schizophrenia (SZ). Objectives To show that pericentriolar material 1
protein (PCM1) forms a complex at the centrosome with disrupted-in-schizophrenia 1
(DISC1) and Bardet-Biedl syndrome 4 protein (BBS4), which provides a crucial pathway for
cortical development associated with the pathology of SZ. To identify mutations in
thePCM1gene in an SZ population. Design Interaction of DISC1, PCM1, and BBS proteins …