[HTML][HTML] Phosphoinositide 3-Kinase and p72syk Noncovalently Associate with the Low Affinity Fcγ Receptor on Human Platelets through an Immunoreceptor Tyrosine …
GW Chacko, JT Brandt, KM Coggeshall… - Journal of Biological …, 1996 - ASBMB
Previously, we have demonstrated that the cytoplasmic tyrosine kinase p72 syk is coupled to
the platelet Fc receptor for IgG (FcγRIIA)(Chacko, GW, Duchemin, AM, Coggeshall, KM,
Osborne, JM, Brandt, JT, and Anderson, CL (1994) J. Biol. Chem. 269, 32435-32440).
Further analysis of the platelet activation by FcγRIIA demonstrated that FcγRIIA is also
inducibly coupled to the serine/threonine and lipid kinase, phosphoinositide 3-kinase (PI 3-
K). Activation of platelets with anti-FcγRIIA antibodies resulted in the noncovalent …
the platelet Fc receptor for IgG (FcγRIIA)(Chacko, GW, Duchemin, AM, Coggeshall, KM,
Osborne, JM, Brandt, JT, and Anderson, CL (1994) J. Biol. Chem. 269, 32435-32440).
Further analysis of the platelet activation by FcγRIIA demonstrated that FcγRIIA is also
inducibly coupled to the serine/threonine and lipid kinase, phosphoinositide 3-kinase (PI 3-
K). Activation of platelets with anti-FcγRIIA antibodies resulted in the noncovalent …