Perforin expression and cytotoxic activity of sputum CD8+ lymphocytes in patients with COPD
G Chrysofakis, N Tzanakis, D Kyriakoy… - Chest, 2004 - Elsevier
Background Previous studies have shown that the inflammatory response to cigarette
smoking differs between smokers who acquire COPD and those who do not, and the CD8+
T-lymphocytes have been identified as a key player in this response. Objective To
investigate the cytotoxic activity and perforin expression of CD8+ lymphocytes in the airway
lumen of patients with COPD. Methods Thirty-six male smokers with COPD, 25 male
smokers without COPD, and 10 healthy nonsmokers participated in the study. T-lymphocytes …
smoking differs between smokers who acquire COPD and those who do not, and the CD8+
T-lymphocytes have been identified as a key player in this response. Objective To
investigate the cytotoxic activity and perforin expression of CD8+ lymphocytes in the airway
lumen of patients with COPD. Methods Thirty-six male smokers with COPD, 25 male
smokers without COPD, and 10 healthy nonsmokers participated in the study. T-lymphocytes …