[HTML][HTML] Conditional expression of fibroblast growth factor-7 in the developing and mature lung

JW Tichelaar, W Lu, JA Whitsett - Journal of Biological Chemistry, 2000 - ASBMB
Effects of fibroblast growth factor-7 (FGF-7) on lung morphogenesis, respiratory epithelial
cell differentiation, and proliferation were assessed in transgenic mice in which the
humanFGF-7 cDNA was controlled by a conditional promoter under the direction of
regulatory elements from either the human surfactant protein-C (SP-C) or rat Clara cell
secretory protein (ccsp) genes. Expression of FGF-7 was induced in respiratory epithelial
cells of the fetal lung by administration of doxycycline to the dam. Prenatally, doxycycline …