Acetylsalicylic acid (ASA) given simultaneously with paracetamol decreased paracetamol-
induced hepatotoxicity (measured by plasma transaminase activities as well as histology)
without any effect on glutathione depletion, indicating that ASA prevents a process (or
processes) subsequent to the metabolic activation of paracetamol. Delayed treatment with
ASA also reduced paracetamol-induced liver toxicity, suggesting that reduction of the
absorption rate of paracetamol does not contribute essentially to the protection by ASA …